Repurposing Hazelnut Waste Products for a Sustainable Economy: A Metabolomic Analysis of Cuticles and Shells to Highlight Their Antioxidant Potential and Inhibitory Activity against Verocytotoxic Escherichia coli

This study evaluated the functional components of hazelnut waste products (cuticles and shells) for potential use in circular economy. HPLC-HRMS ABTS assay were used to determine molecules with properties antioxidant capacity, respectively. The capacity cuticles shells was tested using two different methods extraction (EtOH 50/50 acetone 40/70) by radical cation decolorization assay. growth inhibition effect extracts against porcine O138 E. coli F18+ microdilution bacterial method confirmed determination minimal inhibitory concentration (MIC). results showed that produced a higher yield metabolites compared ethanol extraction, exhibited antimicrobial potential. acetone/water led identification 738 signals 453 detected after EtOH/water extraction. Through metabolomic analysis, it found presented much quantitative qualitative polyphenolic profile than did shells. In addition, revealed had Thus, we believe hazelnut-derived show high sustainable